Thilakavathy Karuppiah

  • Research Overview

    Our group, Stem Cells and Molecular Group (SCMG) is involved in fundamental and applied research related to mesenchymal stem cells (MSCs) and molecular biology studies pertaining to it.  SCMG also engaged in genetic studies related to human genetics disorders and molecular prenatal diagnosis.  Proteomics studies are also one of the interests of this group. 

    Current research projects focus on:

    • Isolation and propagation of amniotic fluid MSCs using various media.
    • Cytogenetics study on amniotic fluid MSCs.
    • Development of microfluidic system prototype for sorting murine bone marrow MSCs.
    • Genetics study on the transformation of murine bone marrow MSCs into sarcoma cells.
    • Mutation screening of Malaysian hypophosphataemic  rickets..
    • Protein profiling of preterm placenta and plasma.

    Research Funding

    Project Title Funding Source
    The contribution of stroma mediated immunosuppressive microenvironment to foetal and adult heamopoiesis MOE
    Foetal DNA in maternal serum and adverse pregnancy outcomes RUGS
    Isolation, propagation and identification of human amniotic fluid mesenchymal stem cells RUGS
    Development of a dielectrophoresis microfluidic Lab-on-Chip device prototype for pure population isolation of untransformed murine bone marrow derived mesenchymal stem cells E-Sc
    THE INFLUENCE OF IN VITRO MICROENVIRONMENT NICHE TO THE GENETIC STABILITY OF HUMAN AMNIOTIC FLUID-DERIVED MESENCHYMAL STEM CELLS FRGS

    Selected Publications

    Karuppiah T, Rosli R, Baskaran TP 2008 Exploring SOD1 Gene for the Detection of Fetal Down Syndrome. Journal of Prenatal Medicine; 2(3): 36 – 39

    Ntimi CM, Rosli R, Adam A, Karuppiah T, Nordin N 2012 Differentiation of transgenic mouse embryonic stem cells (46C) in matured neurons. Regenerative Research; vol 1: 44-45

    Zamanpoor M, Rosli R, Yazid MN, Husain Z, Nordin N, Thilakavathy K 2013 Quantitative Analysis of Fetal DNA In Maternal Plasma In Gestational Diabetes Mellitus, Iron Deficiency Anemia And Gestational Hypertension Pregnancies. The Journal of Maternal-Fetal & Neonatal Medicine; DOI: 10.3109/14767058.2013.766710

    Hooshmand S, Ghaderi A, Yusoff K, Karrupiah T, Rosli R and Mojtahedi Z 2013 Downregulation of RhoGDIα increased migration and invasion of ER+ MCF7 and ER− MDA-MB-231 breast cancer cells. Cell Adhesion & Migration; 7(3): 297-303

    Gao L, Thilakavathy K, Nordin N 2013 A plethora of human pluripotent stem cells. Cell Biology International; DOI: 10.1002/cbin.10120

    Awards

    Year Name of Award
    2002 Gold Medal (Invention & Research exhibition)
    2008 Silver Medal (Invention, Research and Innovation Exhibition)
    2009 Postdoctoral Fellowship
    2012 Excellence Service Award
    2013 Excellence Service Award

  • Thilakavathy Karuppiah

    [email protected]
    Mesenchymal Stem Cells

    603-89472652