Sharmili has a research focus on understanding the inflammatory responses of microglia, the brain's macrophages, and modulating them using mesenchymal stem cells.
With this cellular approach, the Neuroinflammation Group aims to identify the mechanisms and molecules modulated within microglial cells by mesenchymal stem cells to reveal therapeutic strategies for neuroinflammatory conditions.
Working with mouse bone marrow mesenchymal stem cells and mouse microglia, we have shown various responses of microglia including nitric oxide production and proliferation to be modulated by mesenchymal stem cells. We also reveal changes that occur within mesenchymal stem cells when in contact with microglia, revealing cell-cell interactions.
Project Title Funding Source Gene expression and cell migration in mesenchymal stem cell-mediated modulation of microglia. Exploratory Research Grant Scheme ( MicroRNA-mediated immunomodulation of microglia by mesenchymal stem cells. Sciencefund A developmental role for microglia: pinpointing a function for microglia in embryonic neurogenesis Fundamental Research Grant Scheme
Selected PublicationsYin Yin Ooi, Rajesh Ramasamy, Zul’atfi Rahmat, Hemavathy Subramaiam, Shi Wei Tan, Maha Abdullah, Daud Ahmad Israf, Sharmili Vidyadaran 2010 Mesenchymal stem cells suppress microglia proliferation and modulate nitric oxide production. International Immunopharmacology. 10 (12): 1532-1540Yin Yin Ooi, Zul’atfi Rahmat, Shinsmon Jose, Rajesh Ramasamy and Sharmili Vidyadaran. 2013 Immunophenotype and differentiation capacity of bone marrow-derived mesenchymal stem cells from CBA/Ca, ICR and Balb/c mice. World J Stem Cells 5(1): 34-42Zul’atfi Rahmat, Shinsmon Jose, Rajesh Ramasamy and Sharmili Vidyadaran. 2013 Reciprocal interactions of bone marrow-derived mesenchymal stem cells and BV2 microglia following lipopolysaccharide stimulation Stem Cell Research and Therapy 4:12Shinsmon Jose, Shi Wei Tan, Yin Yin Ooi, Rajesh Ramasamy and Sharmili Vidyadaran. 2014 Mesenchymal stem cells exert anti-proliferative effect on lipopolysaccharide-stimulated BV2 microglia by reducing tumour necrosis factor-alpha levels. 1. Shinsmon Jose, Shi Wei Tan, Yin Yin Ooi, Rajesh Ramasamy and Sharmili Vidyadaran. 11:149
Year Name of Award 2008 L’Oreal For Women in Science Fellowship
Mesenchymal Stem Cells