An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production September 3, 2014 by De Ming Chau Comments are off Posted in:De Ming Chau See more Prev:Piperidine acetic acid based γ-secretase modulators directly bind to presenilin-1. Back: All Publications Next:Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.