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Research Overview
Research Funding
Project Title Funding Source Isolating and characterising putative bladder cancer stem cell Universiti Putra Malaysia - Putra Grant Muda Elucidating the role of gamma-secretase and Notch signalling pathway in bladder cancer cells MOE - FRGS Selected Publications
Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM. 2009 Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proc. Natl. Acad. Sci. USA. 106(48): 20228-33Tian Y, Bassit B, Chau DM, Li, YM 2010 An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production Nat. Struct. Mol. Biol. 17(2): 151-8Crump CJ, Fish BA, Castro SV, Chau DM, Gertsik N, Ahn K, Stiff C, Pozdnyakov N, Bales KR, Johnson DS, Li YM 2011 Piperidine acetic acid based γ-secretase modulators directly bind to presenilin-1. ACS Chem Neurosci. 2(12): 705-710Crump CJ, Ende CW, Ballard E, Pozdnyakov N, Pettersson M, Chau DM, et al. 2012 Development of clickable active site-directed photoaffinity probes for γ-secretase Bioorganic & Medicinal Chemistry Letters. 22(8): 2997-3000Chau DM, Crump CJ, Villa, JC, Scheinberg DA, Li YM. 2012 Familial Alzheimer disease Presenilin-1 mutations alter the active site conformation of γ-secretase J Biol Chem 287(21): 17288-17296
Awards
Year Name of Award 2010 Alzheimer’s Drug Discovery Foundation Young Investigator Award 2014 Lindau Nobel Laureate Meeting Young Scientist Award -
De Ming Chau
[email protected] Molecular Cancer Biology
