Cheah Pike See

  • Research Overview

    Pike See is a Senior Lecturer/Researcher at the Department of Human Anatomy, UPM. Having completed her PhD in Anatomy from Universiti Kebangsaan Malaysia, she spent 2 years as a visiting scientist and postdoctoral fellow at the School of Molecular and Biomedical Science, University of Adelaide and Centre for Cancer Biology, South Australia. There, Pike See pursued her interest in the field of neuroscience, focusing on molecular pathways involved in brain development and mechanisms responsible for brain defects through molecular and cellular analysis of mutant and transgenic embryos. Her early research was focused on the role of Sox3  in brain development. Then, she engaged in studies related to neurodevelopmental defects. 

    She is now interested in deciphering the genetic components that regulate the molecular networks underlying the development of the mammalian brain and skeletal muscles. Her current research focus includes:

    • Characterisation of the role of small non-coding RNAs (miRNAs) during brain development
    • Characterisation of novel microRNAs involved in embryogenesis
    • Transcriptomic analysis of Down syndrome mouse brain
    • Functional restoration of neurogenesis& neuronal development in Down syndrome mouse model
    • Searching for genetic culprits in Down syndrome related muscle hypotonia
    • Histomorphometrical studies in skeletal muscle of animal model for Down syndrome
    • Metabolic pathway profiling of Ts1Cje mouse model for Down syndrome
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    Research Funding

    Project Title Funding Source
    Identification of molecular mechanism responsible for hypotonia in adult Ts1Cje mouse model of Down syndrome Research University Grant Scheme/ RUGS)
    Molecular, metabolic and functional characterization of adult skeletal muscle in Down syndrome mouse model : insights into the muscle weakness seen in human condition Grant Putra
    Establishment of the first ”super electroporator” platform in Malaysia for the delivery of bicistronic expression vectors with shRNA and GFP open reading frames into the cerebral cortex of mouse model for Down syndrome. E-science Fund (MOSTI)
    In vivo analysis of a novel miRNA, M1181, during mouse corticogenesis using in utero electroporation (IUE) approach Exploratory Research Grant Scheme/ERGS
    The identification of disrupted molecular networks involved in brain maturation and function in the Ts1Cje mouse model of Down Syndrome Research University Grant Scheme (RUGS)

    Selected Publications

    Rogers N, Cheah PS, Szarek E, Piltz S, Banerjee K, Schwartz J & Thomas PQ. 2013 Expression of the murine transcription factor gene Sox3 during embryonic and adult neurogenesis. Gene Expression Patterns. 13:240-248.

    Cheah PS, Ling KH, Crouse KA and Rosli R. 2007 Characterization of the S-benzyldithiocarbazate effects on cell proliferation and oncogene expression in human breast cancer cells. Journal of Medical and Biological Sciences. 1(2): 1257.

    Szarek E, Cheah PS, Schwartz J, Thomas P. 2010 Molecular genetics of the developing neuroendocrine hypothalamus. Molecular and Cellular Endocrinology, 323: 115-123.

    Kristie Lee, Wong J, Morris M, Rizzoti K, Hughes J, Cheah PS, Felquer F, Liu X, Piltz S, Lovell-Badge R and Thomas PQ 2012 Congenital hydrocephalus and abnormal Subcommissural Organ development in Sox3 transgenic mice. PLOS One. 7(1): e29041.

    Cheah PS, Ramshaw HS, Thomas PQ, Toyo-oka K, Xu. X, Martin S, Coyle P, Guthridge MA, Stomski F, M Van den Buuse, Wynshaw-Boris M, Lopez AF & Schwarz QP. 2012 Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3 ζ deficiency. Molecular Psychiatry 17: 451-466.

    Awards

    Year Name of Award
    2013 BNC-MSN Education Grant Awards. Travel Award to attend Neuroscience 2013, scheduled for June 14-16th , 2013 Kuching, Malaysia.
    2014 Second Prize – Best Poster Presentation (Health Sciences Category). Research Week, Faculty of Medicine & Health Sciences, UPM. 25th – 26th June 2014.
    2014 Third Prize – Best Poster Presentation (Health Sciences Category). Research Week, Faculty of Medicine & Health Sciences, UPM. 25th – 26th June 2014.
    2014 Third Prize – Best Poster Presentation (Special Neuroscience Awards). Research Week, Faculty of Medicine & Health Sciences, UPM. 25th – 26th June 2014.

    Current Lab Members

    Name Position Research Interest Year Joined
    Angeline Leong Jia Wen Postgraduate student Spatiotemporal Expression and Molecular Characterisation of Novel miR-344b and miR-344c in the Developing Mouse Brain 2012
    Chai Ling Lim student Metabolic and functional characterization of adult skeletal muscle in Down syndrome mouse model: Insight into the muscle weakness seen in human condition 2014
    Kai Ling Tan Student Neurogenesis and neuronal-development defects in Ts1Cje 2011
    Student Name PhD candidate Testing 2013
    Usman Bala PhD Cellular and molecular characterization of hypotonia in adult Ts1Cje mouse model for Down syndrome February, 2013
  • Cheah Pike See

    cheahpikesee@upm.edu.my
    Neurogenetics

    +603-8947 2355